Jane Gloriana Villanueva
Jane is a 23-year-old, religious young Latina woman who becomes pregnant after being artificially inseminated by mistake. After meeting Rafael and hearing his situation, she agrees to carry the baby full term and turn over custody to him and his wife Petra, but only if she is sure her baby will be safe and loved with them. But, as the pregnancy grows, they both start to have feelings for each other. Jane ends up having a baby boy named Mateo Gloriano Rogelio Solano Villanueva. She marries Michael Cordero in the season two finale. In the tenth episode of season three, she becomes widowed when he dies from his gunshot wound. She later finds her feelings resurfacing for Rafael again.
Rafael is a 31-year-old ex-owner of the Marbella Hotel and the biological father of Jane's child who has fallen out of love with his wife. As the series progresses, he develops growing feelings for Jane and divorces Petra after discovering her affair. In season two, he has two daughters with Petra and, in season three, briefly goes to jail.
Petra is Rafael's scheming ex-wife and a member of a shady Czech crime family who got married to Rafael in order to steal his wealth, though over time she did fall in love with him. She later divorces Rafael and in Season 2, she gives birth to their twin daughters, Anna and Elsa.
Mateo is Jane and Rafael's baby. Named after Jane's grandfather and Alba's husband, who died before Jane was born.
Rogelio is a self-involved, famous telenovela star and Jane's biological father. In Season 1, he is trying to gain a relationship with his newly discovered daughter. He also has feelings for Xiomara, who was his girlfriend in high school. He marries Xiomara in the season three finale. Rogelio also has a baby with Darci Factor in Season 4.
Xiomara (aka Xo) is Jane's outgoing mother. She was only sixteen years old when she had Jane, which is why Jane would rather keep her virginity until marriage than make the same mistake her mother did. She is a dance teacher but dreams of having a singing career. She marries Jane's father in the Season three finale.
Alba is Jane's pious maternal grandmother (Abuela) and Mateo's great-grandmother (Bisa). She is highly religious and encourages Jane to save her virginity until marriage. Although she rarely speaks English, she understands it, since her granddaughter usually only speaks to her in English. She was in the country illegally until she got her green card in season two.