Luisa is the daughter of Emilio Solano and adoptive-sister of Rafael. Luisa thought her mother passed away when she was 6, but discovered 30-some-odd years later that her mother had faked her own death and lived out her life in a cottage by a lake, presumably to escape Emilio Solano and his business with the criminal Mutter. Luisa shares a close relationship with her brother, who put up his share of The Marbella as collateral in case Luisa ever gets sued for malpractice.
Luisa has had a difficult childhood, her mother gone, her father remarrying multiple times, and is a recovering alcoholic. Although she is close with Rafael, they share an antagonistic relationship at times, which is rooted in her alcoholism and Rafael's issues with his own mother. The most loving relationship Luisa seems to have had is with Rose, although there is no trust there, Rose being Sin Rostro and having murdered Luisa's father in cold blood.
Luisa is first introduced as the stable, supportive older sister of a frazzled Rafael Solano. She gives advice and supports him, is married – everything seems comfortable. This is just the beginning of the tale of Luisa Alver. After her wife cheats on her, she's distraught and accidentally inseminates Jane instead of Petra. She fears a lawsuit and contacts her old flame, who turns out to be her father's wife, with whom she still occasionally carries on an affair. Luisa is a recovering alcoholic, who falls off the wagon when she temporarily leaves Miami on a drinking bender, nobody knowing where she is and Rose worries about her.
Luisa returns for Jane's lawsuit against her, which has gotten Rafael fired by his father. She decides to deal with the fact that she is in love with Rose in an adult way, and confronts Rose, the latter has her committed to a mental institution – with the help of Luisa's father and brother! Needless to say Luisa isn't feeling supported and so when Rose appears, Luisa yells at Rose and throws her out, but later gives in as she feels alone and unloved. When Rose is revealed as Sin Rostro, Luisa is shocked and overwhelmed – even moreso when a Rose on the run from the law asks Luisa to run away with her.
To get some space from the crazy elitist world in which she grew up, her father's death and her heartache, Luisa hands over temporary custody of her share of The Marbella to Petra, and leaves for an ashram for quite a while. Upon returning, she has a new girlfriend and is interested in helping Rafael rectify the reputation of The Marbella, and throws a pro-wrestling match. She also advices Rafael yet again on his future with Jane, repeating that money is not the answer to anything in their lives and it's best to let it go, which Rafael takes to heart.
For however functional Luisa seemed at the time of Mateo's birth, she is now distraught after her girlfriend breaks up with her over Rose and Luisa seeks new purpose in her life when a conversation-turned-gossip-article with Jane's scheming class mate, Wesley, alerts her to the thought that maybe her mother never did kill herself. Luisa checks the burial chamber where her mother should be resting and find it is empty. Following this discovery, Luisa goes to the police and starts collaborating with Michael Cordero and Susanna Barnett, the latter of whom Luisa develops a crush on. The investigation leads them to the mental institution where Mia Alver was registered and her name is still amongst the tenants, but Luisa finds that the woman carrying her mother's name is mute – and not Mia Alver.
Susanna and Michael tell Luisa their theory that Mia Alver is the notorious crime lord Mutter and Luisa is, understandably, devastated – and in turn, connects Rose and her mother's similar influences in her life. Luisa and Susanna get closer and share a kiss, but Susanna breaks it off – at first. They begin a fling, but Susanna ends it when Luisa works as a decoy in the Sin Rostro investigation, and confesses her eternal love for Rose. Luisa offers herself up as a "target" to lure out Rose, which ends up with Rose found dead in front of a devastated Luisa. Though she wishes to move forward with Susanna, the latter suggests that Luisa return to rehab to recover and get over Rose and that they can start anew once she returns.
Upon leaving rehab, Luisa seems better and ready to start her life over – with Susanna. The two attend Jane and Michael's wedding together, but Luisa is shocked to discover that Susanna is actually Rose in disguise, who asks Luisa to come away with her.
Having just shot Michael disguised as Susanna, unbeknownst to Luisa, Rose kidnaps Luisa and brings her to her current hideout – a submarine circling the same spot. They spend two months together on the submarine during which they have lots of sex while Rose attempts to convince Luisa that the two of them can be together now – in spite of the fact that Rose is a serial killer, who also happened to murder Luisa's father. Luisa doesn't see a future for them and, though it is dubious, Luisa resurfaces to tell Rafael and Michael that she was with Rose but left her and that's the end of it.
Luisa finds it hard to actually have left this whole ordeal behind and seeks out the support of her brother. Rafael, doing Rogelio a favour, asks him to spend some time with Luisa. While an unusual combination, Rogelio's theatre advice acts as inspiration for Luisa, who decides to enter preventative rehab to take care of herself without all the crises of her past.
In 2010, Rose and Luisa meet at a bar and instantly connect. They talk, take a walk and make love several times in a pool under 4th of July fireworks. Following their rendezvous, Luisa attends a tense family dinner with her father and brother the next night, and Rose walks in, introduced as Emilio's date. While in the subsequent years, Luisa marries her then-girlfriend Allison (who is found cheating in the Pilot) and Rose marries Emilio Solano, Rose and Luisa are secretly lovers (whether this happens in between their first meeting in 2010 and Season 1, is unclear). Even after discovering that Rose is a Crime Lord going by the name Sin Rostro, Luisa's feelings for Rose are unchanged and vice versa.
Following the revelation that Rose is Sin Rostro and Luisa's subsequent discovery of the site of the murder of her and Rafael's father, Emilio, Luisa leaves town. This also follows the Miami Police Department tapping her phone and intercepting a call from Rose to Luisa. The assumption is that Luisa went to be with Rose, but she returns with a new girlfriend – Jordan. 'Juicy Jordan' is a show wrestler and Luisa, wanting to showcase her new squeeze, puts on a match night at The Marbella. Jordan and Luisa are very cutesy and making out fiercely regardless of who's in the room or whether they were in the middle of a conversation.
Luisa appears to be somewhat coddled by her father, which is also expressed by Rafael when Emilio takes Luisa's insemination of Jane very calmly. Emilio's favourable treatment of Luisa over Rafael could be because Luisa fulfills the criteria for life that Emilio values: she went to school, became a doctor and has a job (until Chapter Two, anyway). Luisa never refutes any of the lenience her father bestows upon her, neither does she seem, however, incredibly fond of him, as she later describes him as not being a good father. She still calls him daddy, though, and seems to get along with him just fine before he is murdered.
Luisa first comes off as Rafael's rock of support in Rafael's wish to end his marriage to Petra. However, their relationship is at times a roller coaster, largely due to Luisa's alcoholism and her wavering presence in his life. When Luisa is sent to the mental hospital by Rose and Emilio and is later released, she is incredibly hurt by Rafael's lack of support and reminds him of how she has always supported him (when she was around). They reconnect and disperse throughout the series. Lately, Rafael is furious at Luisa when he finds out that she kept in contact with Sin Rostro, who kidnapped his son and her newphew, Mateo, for 6 months and Rafael has not been a part of the police investigation into Luisa's mother.
Jordan – You saved things from your psychopath ex-girlfriend?!
Luisa – Okay, first of all she's not a psychopath – she's a sociopath