A doctor's office mishap causes Jane to become pregnant with a specimen meant for someone else in the series premiere of this comedy-drama about a chaste young woman who struggles to tell her religious family about her unplanned in-vitro pregnancy.
Jane's mom pressures her to sue her doctor. Meanwhile, Jane keeps crossing paths with Rafael; jealousy propels Michael to seek out Petra as an ally; and Jane's father wants to meet her, but Xiomara is not ready for this yet.
Alba gets proactive about keeping Rogelio away from Jane because she doesn't like Xo's approach. Meanwhile, Jane contemplates making a big change in her relationship with Michael; and Jane continues to question Petra's maternal abilities.
Jane experiences guilt concerning her feelings for Rafael, and she admits this to Michael. Meanwhile, an unwelcome visitor from Petra and Rafael's past surfaces; and Rogelio asks Xo to allow him to be involved in Jane's wedding.
Jane moves in with Michael after she gets mad at Xo, but then she reconsiders her hasty actions. Meanwhile, Rogelio grows anxious when Jane plans to meet with him; and Rafael and Petra continue to have marital problems.
Jane bonds with Rogelio until she meets his stepdaughters, who aren't very nice to her. Meanwhile, Rogelio persuades Xo to hire his band; Petra gets her husband arrested; and Jane wrestles with how to proceed in her relationship with Michael.
A music producer contacts Xo about recording a demo, but Xo's unaware that Rogelio is behind this. Meanwhile, Jane and Rafael share surprising secrets with one another; Michael comes close to solving his case; and Petra won't make things easy for Rafael.
Xo meets her idol when she attends an awards show with Rogelio, Jane and Alba. Meanwhile, a secret of Petra's is uncovered by Jane and Rafael, leading them to worry about how she really feels regarding the baby.
A hurricane hits town, forcing Jane to stay at the Marbella. Meanwhile, Rogelio comforts Xo when he learns about Alba's condition; Rafael gets his old job back and must make a tough call regarding staff layoffs; and Michael tries to assist Alba quietly.
Jane is torn when she is offered a permanent position at the Catholic high school, even as Rogelio offers her a writing internship at his telenovela. Alba tells Xo to keep the promise she made about Rogelio. Meanwhile, Michael goes against his boss's orders when his suspicions grow that Rafael is involved with Sin Rostro.
Jane gets her big break in her new career writing, but she correctly suspects Rogelio is involved in getting her the job. Jane learns that her first work assignment is to write Rogelio's character Santos being killed off. Rafael continues to be skeptic to Rose's accusations that his father is Sin Rostro. Meanwhile, Petra's past finally catches up with her when her former lover, the violent Czech gangster Milos, arrives and is determined to win her back any way he can, which includes revealing Magda's secret that she has been keeping from her. Jane and Rafael visit Luisa still confined to the mental hospital where Rafael does not want to be drawn back into his estranged sister's drama any more, while Luisa gives Jane a confidential letter to give to Rose. Elsewhere, Michael, despite being suspended from the police force due to the jealous and vindictive Nadine ratting him out, continues his own investigation with more determination then ever to expose any connection between Rafael and Sin Rostro by investigating the plastic surgeon who may be connected to the hotel. In a shocking twist ending, a recurring character is killed off, and the identity of Sin Rostro is finally revealed.
Jane and Rafael are eager to know the baby's gender. Though, they experience medical problems, and Jane may miss her graduation. Meanwhile, Alba keeps quiet about something she is humiliated to talk about to her daughter, Xo. Elsewhere, Michael believes he has found out who Sin Rostro is, but he must capture him before he flees.
Michael attempts to convince Jane that Rafael is involved with hiding his father's involvement, which he succeeds as Jane questions her baby's father. Xo and Rogelio are at odds when they are forced to speak with each other. Petra discovers a new way to make Rafael's life more miserable. Meanwhile, Jane questions her future with Rafael when her friends throw her a baby shower.
Jane and Rafael receive exciting news about their baby's health. They resume the topic of moving in together and Rafael surprises Jane. Alba gives bad advice to Jane and Xo. Meanwhile, Petra makes an ally with Rafael when Lachlan attempts to blackmail her to resign her co-owership of the hotel. Also, Michael informs Jane about her favorite author visiting the Marbella.
When Jane gets a case of writers block due to the tension between her and Rafael, she signs herself up for a romance writing workshop for research, and she thinks she has found her solution. Meanwhile, Petra tries to find a musical performer for the Mirabella's Calle Ocho celebration, but it forces her to team up with Rafael to ask Rogelio for help. Also, Rogelio is struggling with his new character as a detective, so he gets the brilliant idea to tag along with Michael for real cop experience, who at the same time, is investigating Roman Zazo's murder by tailing a suspected drug dealer. Elsewhere, Xo makes a decision to move in with Rogelio which causes a rift between her and Alba.
Jane does more research about pregnancy as well as nursing, which leads herself to volunteer to babysit for her new friend Andi's infant niece. Jane is unaware that Andi happens to be Michael's former girlfriend from years ago. Andi finds out who Jane is and decides to use that to try to win Michael back. Meanwhile, Rafael and Petra become overwhelmed while planning a party to bring in more business for the failing Mirabella. But when things take a turn for the worse, Rafael takes what happens very badly which makes Jane wonder if parenthood is the right thing for him. Xo and Alba continues to be estranged following Xo moving in with Rogelio who is oblivious to Xo's advances to make him say "I love you" to her. Also, Rogelio and Michael grow closer as friends, which makes both Jane and Rafael uncomfortable. Elsewhere, Petra continues to be curious about Aaron Zazo, but she becomes unsettled when she suspects that Aaron may in fact be Roman.
After Jane unintentionally ruins Rafael's chances of getting the hotel's liquor license back when she mouths off to the abrasive and cold-hearted city counselwoman Alexis Falco, he persuades her to become chummy with the antagonistic Alexis to make things right. But Jane learns that she will have to miss her family's annual Easter dinner and festivities. Meanwhile, Rafael gets information about his birth mother from the private detective he has hired, but the long-awaited reunion with his mother doesn't go very well when Rafael learns the truth about his mother's departure which mirrors the problems he currently has with Jane. Rogelio's equally vain and shallow mother, Liliana (guest star Rita Moreno), comes for a visit, but she and Xo do not get along at all due to their bad history. Alba takes a big step in her growing romance with Edward (guest star Cheech Marin), the man in her physical therapy class, by asking him out on a date, but she later finds out from Jane that he happens to be a priest. Also, Jane finally finds out that Michael is Andie's former girlfriend, but she says nothing so that Michael can stop pouting after her. Elsewhere, Petra becomes more convinced that Aaron is actually somehow really Roman (even though Roman was impaled by an ice sculpture). She enlists Michael's help to get confirmation.
Jane becomes desperate to fix things with Rafael and suggests working on a way to help them move past their problems by seeing a couples therapist. Lina throws a baby shower for Jane with everyone attending which makes Rafael realize that although he does love Jane, their differences continue to fill him with doubt about a future together. Jane finally confronts Andie about investigating her in order to win Michael back, and is forced to come clean to Michael about it. Meanwhile, Xo has been keeping a secret from Rogelio about kissing another guy, but when she finally comes clean to him after seeing him flirt with Jane's workshop mentor, Rogelio's negative reaction surprises her. Alba has a flashback of who pushed her down the stairs when she sees Petra's mother from a distance. Still dealing with the Sin Rostro aftermath, Michael makes an upsetting discovery about who was involved in stopping his investigation all along. Elsewhere, Petra finds herself in a dire situation leaving her to save herself from Roman/Aaron Zazo who holds her captive at a remote cabin in a swamp.
Jane deals with the aftermath after her breakup with Rafael, feeling pressured that she must now do things on her own. Jane reports to Michael of the new evidence in Alba's accident. Petra's mother returns to Florida, and it causes stress for Jane since she knows that Magda attempted to murder Alba. Meanwhile, Xiomara attempts to fix things with Rogelio, but the egotistical actor is not quick to forgive despite his own shortcomings. Also, Rafael's sister, Louisa, returns to town with a new girlfriend, a pro-wrestler, and suggests holding a "wrestling brawl" to bring in some short-term money and publicity for the hotel. Alba's suitor, Edward, again asks her out on a date and Alba accepts despite not knowing where it will lead. When Petra, Magda, along with their former captive Ivan, cover up the attempt on Alba's life and Rafael buys their side of the story (that Alba was drunk and unaware of her surroundings) Jane decides to take long-term action.
Jane tells Rafael about her decision to sue him for sole custody of the baby. Petra, after causing tension between her and Jane, tries to fix the issue after Rafael confides in Petra about Jane's decision. Meanwhile, Jane attends her five-year high school reunion, but she confesses that she did not expect what her life would do at the moment. Xo and Rogelio rehearse for their show, but Xo remains confused as why Rogelio is acting odd. Elsewhere, Jane agrees to attend Michael's police force commendation, but sets a few ground rules.
Jane falls into false labor, but she insists her parents go to their show in Las Vegas, Nevada. However, when they leave, Jane really does go into labor. Xo attempts everything she can to return back to Florida, but Rogelio feels as if he is left out. Michael and Rafael try to make things easier for Jane during her labor, but their presence causes only tension for both of them. Alba is excited to tell her special friend about the baby's arrival. Meanwhile, Petra discovers some worrisome news about Rafael and contemplates whether to tell him or not. Also, Michael's former partner, Nadine, shows up where she wants to cooperate with him in tracking down Sin Rostro. In a series of climatic twists, Jane gives birth to a baby boy, not a girl as she was expecting. She names the baby Mateo Gloriano Rogelio Solano Villanueva. Nadine escapes from Michael's custody, only he lets her escape hoping that she will lead him to Sin Rostro. Xo and Rogelio learn that they got married during a drunken bender back in Vegas. Petra decides to not tell Rafael that his sperm was split into two samples, and Petra takes the second sample of Rafael's sperm away from the sperm bank for herself. A nurse quietly snatches Jane's baby from the nursery at the hospital and gives it to Rose (Sin Rostro) who takes the baby away with her in a limousine for places unknown.